Brush biopsy effective detection of early nasopharyngeal carcinoma

University of Hong Kong , University of Toronto and Queen Elizabeth Hospital , jointly developed new approach to detect early nasopharyngeal carcinoma; this new method is simple and noninvasive to perform oral nasopharyngeal screening.

HKU Li Ka Shing Faculty noted, the three institutions research on trans-oral swab through the mouth into the nasopharynx, then collect cells from the area of the nasopharynx where NPC first forms. This research recruited 600 people, including patients diagnosed of NPC and other participate who has NPC symptoms or suspect to have NPC. All of the participants used this method to take sample through the oral nasopharyngeal. The collected sample went through Polymerase chain reaction (Q-PCR) technical analysis, to detect whether there are hidden EBV DNA and through pathological diagnosis confirmed of nasopharyngeal cancer. The results showed, samples taken from oral nasopharyngeal screening method shows highly sensitivity and specificity up to 99%, with misdiagnosis rate of only 1%, a better detection method then the current existing tests.

Led researcher, Dr. Raymond Ng, assistant Professor, Department of Otolaryngology – Head and Neck Surgery at the University of Toronto noted, EBV infection is a key factor and a necessary factor in NPC development. With the new method to collect samples from oral nasopharyngeal and Q-PCR analysis can detect EBV DNA to diagnose whether the risk of nasopharyngeal carcinoma.

HKU School of Medicine, Department of Clinical Professor Wei Lin said to hope that the new test method can be applied to large-scale global nasopharyngeal carcinoma screening, especially in places lack of specialists, precision instruments and endoscopic equipment and tumor sample storage.

After ten years of research, University of Hong Kong , Queen Elizabeth Hospital, in conjunction with the University of Toronto, developed a non- invasive detection of NPC, researchers in Canada and the US are comprehensively promoting this method.

Broadcast by: ontv
Broadcast date: 2014-03-19

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